Native mass spectrometry (MS) is a research area that focuses on the analysis of biomolecules, such as proteins, nucleic acids, and carbohydrates, in their native or near-native states. This technique allows researchers to study the structure, interactions, and dynamics of these biomolecules in their natural environment, without the need for extensive sample preparation or modification. Native MS involves ionizing biomolecules in the gas phase and measuring their mass-to-charge ratio, providing information on the molecular weight and composition of the biomolecules. By studying biomolecules in their native states, researchers can gain insights into important biological processes, such as protein folding, protein-protein interactions, and post-translational modifications. Overall, native MS is a powerful tool for studying biomolecular structures and interactions, and is widely used in fields such as structural biology, biochemistry, and drug discovery.